2012.09-2016.06  乐山师范学院化学学院应用化学专业,本科生；

2016.09-2019.06  兰州大学化学化工学院有机化学专业,硕士研究生；

2024.07-2025.08   峨眉山鸿森生物医药股份有限公司,研发部技术顾问；

2025.11-至今     乐山师范学院新能源材料与化学学院,专任教师。

1.萜类及大环内酰胺类天然产物全合成

2.多肽偶联药物开发及抗菌类小分子药物设计合成

1.基于应对细菌耐药性的新型糖肽类抗生素的合成与生物活性研究 乐山师范学院青年教师科研启动基金项目

发表文章

1. Li, T.; Tang, Z.; Zhang, R.; Challa, M.; Gong, H.; Gong, Z.; Zou, C.; Zhang, S.-L.; Guo, J.; He, Y. Targeted vancomycin delivery via in situ albumin conjugation and acid-triggered drug release for reduced nephrotoxicity. Eur. J. Med. Chem. 2025, 291, 117652.

2. Li, T.; Zhang, R.; Gong, H.; Tang, Z.; Li, X.; Gong, Z.; Challa, M.; Zou, C.; Zhang, S.-L.; Guo, J.; He, Y. Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections. Eur. J. Med. Chem. 2025, 289, 117483.

3. Li, T.; He, X.; Tao, W.; Zhang, R.; He, Q.; Gong, H.; Liu, Y.; Luo, D.; Zhang, M.; Zou, C.; Zhang, S. L.; He, Y. Development of membrane-targeting TPP (+)-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections. Eur. J. Med. Chem. 2024, 264, 115973.

4. Li, T, Guangmiao Wu, Shangbiao Feng, Zemin Wang, Xingang Xie and Xuegong She. A rapid construction of the ABC tricyclic skeleton of malabanone A. Org. Biomol. Chem., 2018, 16, 8491–8494.

5. Li T, Guangmiao Wu, Shangbiao Feng, Xiaojun Hu, Weiwei Zhang, Shouchu Tang, Xingang Xie, Xuegong She. Concise formal synthesis of (+)-pyripyropene A. Tetrahedron 75 (2019) 3939e3942.

6. Shangbiao Feng, Tao, Li. et al. Chem. Commun. 2017, 53, 4585—4588.

7. Guangmiao Wu, Tao, Li, Fuhai Liu, Yulong Zhao, Shiqiang Ma, Shouchu Tang, Xingang Xie*, Xuegong She, Tetrahedron Lett. 2021, 81, 153315.

8. Shangbiao Feng, Jinlai Li, Feifei He, Tao, Li, Huilin Li, Xiaolei Wang, Xingang Xie and Xuegong She. Org. Chem. Front., 2019, 6, 946-951.

9. Huang, D.; Liu, Q.; Zhang, M.; Guo, Y.; Cui, Z.; Tao, Li.; Luo, D.; Xu, B.; Huang, C.; Guo, J.; Tam, K. Y.; Zhang, M.; Zhang, S.L.; He, Y. A mitochondria-targeted phenylbutyric acid prodrug confers drastically improved anticancer activities. J. Med. Chem. 2022, 65 (14), 9955-9973.

10. Huang, D.; Zhang, M.; Zhang, H.; Cui, Z.; Luo, D.; Li, T.; Li, X.; He, Y.; Zhang, S.-L. Design and synthesis of TPP+-Mitomycin C conjugate with reduced toxicity. Bioorg. Med. Chem. Lett. 2022, 77, 129036.